Website Endnotes2018-07-18T02:08:50+00:00

Website Endnotes

Efficacy Claims

Calvano TP, Sill JM, Kemp KR, Chung KK. Use of a high-flow oxygen delivery system in a critically ill patient with dementia. J Respiratory Care. 2008 Dec; 54(12): 1739-43. (Case Study, n=1)

Chatila W, Nugent T, Vance G, Gaughan J, Criner G. The effects of high-flow oxygen on exercise in advanced obstructive airways disease. CHEST. 2004; 126(4): 1108-1115. (Mechanistic: Human, Prospective, Repeated Measures, Single Site, n=10)

Collins C, Holberton J, Barfield C, Davis P. A randomized controlled trial to compare heated humidified high-flow nasal cannulae with nasal continuous positive airway pressure postextubation in premature infants. J Pediatrics. 2013 May; 162: 949-54. (Clinical Trial, Prospective, Randomized, Multicenter, n=132)

Dysart K, Miller T, Wolfson M, Shaffer T. Research in high flow therapy: Mechanisms of action. Respiratory Medicine. 2009; 103: 1400-05. (Review)

Frizzola M, Miller T, Rodriguez ME, Dysart K. High-flow nasal cannula: Impact on oxygenation and ventilation in an acute lung injury model. Ped Pulmonology. 2011 Jan; 46(1): 67-74. (Mechanistic: animal, Prospective, Repeated Measures, Single Site, n=13)

Hasani A, Chapman TH, McCool D, Smith RE, Dilworth JP, Agney JE. Domiciliary humidification improves lung mucociliary clearance in patients with bronchiesctasis. Chronic Respiratory Disease. 2008; 5: 81-86. (Clinical Trial, Prospective, Not Randomized, Single Site, n=10)

Hui D, Morgado M, Chisholm G, Withers L, Nguyen Q, Finch C, Frisbee-Hume S, Bruera Eduardo. High flow oxygen and bilevel positive airway pressure for persistent dyspnea in patients with advanced cancer: a phase II randomized trial. 2013 Oct; 46(4): 463-73. (Clinical Trial, Prospective, Randomized, Single Site, n=23)

Johnson S, Smith R, Ford J, Herr D, Straumanis J, Stein D, Shanholtz C. Humidified high-flow therapy via nasal cannula for acute respiratory failure. 2010 (Abstract, Retrospective, Not Randomized, Single Site, n=331)

Kugleman A, Riskin A, Said W, Shoris I, Mor F, Bader D. A randomized pilot study comparing heated humidified high-flow nasal cannulae with NIPPV for RDS. Pediatric Pulmonology, 2014 Mar 12; 50(6) 576-83. (Clinical Trial, Prospective, Randomized, Single Site, n=76)

Lavizarri A, Colnaghi M, Ciuffini F, Veneroni C, Musumeci S, Cortinovis I, Mosca F. Heated, humidified high-flow nasal cannula vs nasal continuous positive airway pressure for respiratory distress syndrome of prematurity – a randomized clinical noninferiority trial. JAMA Pediatr. 2016 Aug 8. (Clinical Trial, Prospective, Randomized, Single Site, n=316)

Mayfield S. Bogossian F, O’Malley L, Schibler A. High-flow nasal cannula oxygen therapy for infants with bronchiolitis: Pilot study. J Peadiatr Child Health. 2014; 50: 373-78. (Clinical Trial, Prospective, Single Site, n=61).

McKiernan C, Chua LC, Visintainer PF, Allen H. High flow nasal cannula therapy in infants with bronchiolitis. J of Pediatrics. 2009; 156(4): 634-38. (Clinical Trial, Retrospective, Not Randomized, Single Site, Cohort Analysis)

McQueen M, Rojas J, Sun Shyan, Tero R, Ives K, Bednarek F, Owens L, Dysart K, Dungan G, Shaffer T, Miller T. Safety and long term outcomes with high flow nasal cannula therapy in neonatology: a large retrospective cohort study. J Pulm Respir Med. 2014 Dec; 4(6): 216. (Clinical Trial, Retrospective, Not Randomized, Multicenter, Cohort Analysis, n=1363)

Miller T, Saberi B, Saberi S. Computational fluid dynamics modeling of extrathoracic airway flush: evaluation of high flow nasal cannula design elements. J of Pulmonary & Respiratory Med. 2016; 6(5). (Bench, Prospective, Not Randomized, Single Site)

Nishimura M. High-flow nasal cannula oxygen therapy in adults. J of Intensive Care. 2015 Mar 31; 3(15). (Review)

Price A, Plowright C, Makowski A, Misztal B. Using a high-flow respiratory system (Vapotherm®) within a high dependency setting. Nurs Crit Care. 2008 Oct 19; 13(6): 298-304. (Clinical Trial, Observational, Not Randomized, Single Site, n=72)

Rea H, McAuley S, Jayaram L, Garrett J, Hockey H, Stoey Louanne, O’Nonnell G, Haru L, Payton M, O’Donnell K. The clinical use of long-term humidification therapy in chronic airway disease. Respiratory Medicine. 2010 Apr; 104(4): 525-533. (Clinical Trial, Prospective, Randomized, Single Site, n=108)

Shepard J, Burger C. Nasal and oral flow-volume loops in normal subjects and patients with obstructive sleep apnea. American Rev Respir Dis. 1990 Jan;142(6 Part 1): 1288-93 (Mechanistic: Human, Prospective, Single Site, n=28)

Spivey S, Ashe T, Dennis R, Graham R, Melton B, Crot S, Ellis T, McCarl T, Miller J, Anderson S, Green T, Dunlap C, Kolnsberg M, Miller T. Assessment of high flow nasal cannula therapy use in the emergency department setting: observations of practice across four systems. Respiratory Therapy. 2015: 10(1); 30-4. (Non-Peer Reviewed, Prospective, Not Randomized, Multicenter, n=129)

Wilkinson D, Andersen C, O’Donnell CPF, De Paoli AG, Manley BJ. High flow nasal cannula for respiratory support in preterm infants. Cochrane Database of Systematic Reviews. 2016 Feb 22; 2. (Review, Pooled data sample).

Woodhead DD, Lambert DK, Clark JM, Christensen RD. Comparing two methods of delivering high-flow gas therapy by nasal cannula following endotracheal extubation: a prospective, randomized masked crossover trial. J of Perinatology. 2006; 26(8): 481-5. (Clinical Trial, Prospective, Crossover, Single Site, n=30)

*Please note: Additional data in support of Vapotherm’s efficacy claims is compiled, but under review for publication and at this time is not available for disclosure

Utilization Claims

Bressan S, Balzani M, Krauss B, et. al. High-flow nasal cannula oxygen for bronchiolitis in a pediatric ward: a pilot study. Eur J Pediatr. 2003; 172(12): 1649-56. (Clinical Trial, Observational, Not Randomized, Single Site, n-27)

Calvano TP, Sill JM, Kemp KR, Chung KK. Use of a high-flow oxygen delivery system in a critically ill patient with dementia. J Respiratory Care. 2008 Dec; 54(12): 1739-43. (Case Study, n=1)

Collins C, Holberton J, Barfield C, Davis P. A randomized controlled trial to compare heated humidified high-flow nasal cannulae with nasal continuous positive airway pressure postextubation in premature infants. J Pediatrics. 2013 May; 162: 949-54. (Clinical Trial, Prospective, Randomized, Multicenter, n=132)

Dysart K, Miller T, Wolfson M, Shaffer T. Research in high flow therapy: Mechanisms of action. Respiratory Medicine. 2009; 103: 1400-05. (Review)

Herr D, Smith R. Use of high flow nasal cannula (HFNC) 02 therapy for failed extubation post cardiac surgery. Crit Care Med. (Abstract, Retrospective, Not Randomized, Single Site, n=39)

Kugleman A, Riskin A, Said W, Shoris I, Mor F, Bader D. A randomized pilot study comparing heated humidified high-flow nasal cannulae with NIPPV for RDS. Pediatric Pulmonology, 2014 Mar 12; 50(6) 576-83. (Clinical Trial, Prospective, Randomized, Single Site, n=76)

Lavizarri A, Colnaghi M, Ciuffini F, Veneroni C, Musumeci S, Cortinovis I, Mosca F. Heated, humidified high-flow nasal cannula vs nasal continuous positive airway pressure for respiratory distress syndrome of prematurity – a randomized clinical noninferiority trial. JAMA Pediatr. 2016 Aug 8. (Clinical Trial: Prospective, Randomized, Single Site, n=316)

Locke R, Wolfson M, Shaffer T, Rubenstein S.D, Greenspan J. Inadvertent administration of positive end-distending pressure during nasal cannula flow. J Pediatrics. 1993; 91(1): 135-8. (Mechanistic: Human, Prospective, Repeated Measures, Single Site, n=13)

Mayfield S. Bogossian F, O’Malley L, Schibler A. High-flow nasal cannula oxygen therapy for infants with bronchiolitis: Pilot study. J Peadiatr Child Health. 2014; 50: 373-78. (Clinical Trial, Prospective, Single Site, n=61).

McQueen M, Rojas J, Sun Shyan, Tero R, Ives K, Bednarek F, Owens L, Dysart K, Dungan G, Shaffer T, Miller T. Safety and long term outcomes with high flow nasal cannula therapy in neonatology: a large retrospective cohort study. J Pulm Respir Med. 2014 Dec; 4(6): 216. (Clinical Trial, Retrospective, Not Randomized, Multicenter, Cohort Analysis, n=1363)

Miller T, Saberi B, Saberi S. Computational fluid dynamics modeling of extrathoracic airway flush: evaluation of high flow nasal cannula design elements. J of Pulmonary & Respiratory Med. 2016; 6(5). (Bench, Prospective, Not Randomized, Single Site)

Numa A, Newth C. Anatomic dead space in infants and children. J Appl. Physiol. 1996; 80(5): 1485-89. (Mechanistic: Human, Prospective, Single Site, n = 40)

Price A, Plowright C, Makowski A, Misztal B. Using a high-flow respiratory system (Vapotherm®) within a high dependency setting. Nurs Crit Care. 2008 Oct 19; 13(6): 298-304. (Clinical Trial, Observational, Not Randomized, Single Site, n=72)

Shoemaker MT, Pierce MR, Yoder BA, DiGeronimo RJ. High flow nasal cannula versus nasal CPAP for neonatal respiratory disease: a retrospective study. J Perinatol. 2007; 27(2): 95-91. (Clinical Trial, Retrospective, Single Site, Cohort Analysis)

Spentzas T, Minarik M, Patters A, Stidham G. Children with respiratory distress treated with high flow nasal cannula. J of Intensive Care Medicine. 2009 Aug; 24(5):323-8. (Clinical Trial, Retrospective, Not Randomized, Single Site, n= 46)

Spivey S. Case report from Athens: COPD patients with hypercapnia. 2014. (Case Study, Single Site, n=1)

Spivey S, Ashe T, Dennis R, Graham R, Melton B, Crot S, Ellis T, McCarl T, Miller J, Anderson S, Green T, Dunlap C, Kolnsberg M, Miller T. Assessment of high flow nasal cannula therapy use in the emergency department setting: observations of practice across four systems. Respiratory Therapy. 2015: 10(1); 30-4. (Non-Peer Reviewed, Prospective, Not Randomized, Multicenter, n=129)

Wilkinson D, Andersen C, O’Donnell CPF, De Paoli AG, Manley BJ. High flow nasal cannula for respiratory support in preterm infants. Cochrane Database of Systematic Reviews. 2016 Feb 22; 2. (Review, Pooled data sample).

Performance Claims

Atwood C, Miller T, McMillan N, Hartwig K, Camhi S, Schweikert H. Effect of high flow highly humidified air via nasal cannula on respiratory effort in patients with advanced COPD. 2011 Oct; 10(4). (Abstract, Prospective, Randomized, Single Site, n=32)

Chatila W, Nugent T, Vance G, Gaughan J, Criner G. The effects of high-flow oxygen on exercise in advanced obstructive airways disease. CHEST. 2004; 126(4): 1108-1115. (Mechanistic: Human, Prospective, Repeated Measures, Single Site, n=10)

Dysart K, Miller T, Wolfson M, Shaffer T. Research in high flow therapy: Mechanisms of action. Respiratory Medicine. 2009; 103: 1400-05. (Review)

Franchini M, et. al. Oxygen with cold bubble humidification is no better than dry oxygen in preventing mucus dehydration, decreased mucociliary clearance, and decline in pulmonary function. Chest. 2016 Aug; 150(2): 407-14. (Clinical Trial, Prospective, Randomized, Single Site, n=18)

Frizzola M, Miller T, Rodriguez ME, Dysart K. High-flow nasal cannula: Impact on oxygenation and ventilation in an acute lung injury model. Ped Pulmonology. 2011 Jan; 46(1): 67-74. (Mechanistic: animal, Prospective, Repeated Measures, Single Site, n=13).

Locke R, Wolfson M, Shaffer T, Rubenstein S.D, Greenspan J. Inadvertent administration of positive end-distending pressure during nasal cannula flow. J Pediatrics. 1993; 91(1): 135-8. (Mechanistic: Human, Prospective, Repeated Measures, Single Site, n=13)

Miller S, Dowd S. High-flow nasal cannula and extubation success in the premature infant: a comparison of two modalities. J Perinatology. 2010; 30: 805-08. (Clinical Trial, Prospective, Randomized, Single Site, n=40)

Miller T, Saberi B, Saberi S. Computational fluid dynamics modeling of extrathoracic airway flush: evaluation of high flow nasal cannula design elements. J of Pulmonary & Respiratory Med. 2016; 6(5). (Bench, Prospective, Not Randomized, Single Site)

Parke R, Eccleston M, McGuinness S. The effects of flow in airway pressure during nasal high-flow oxygen therapy. J Resp Care. 2011 Aug; 56(8): 1551-1155. (Mechanistic: Human, Prospective, Single Site, n=12)

Price A, Plowright C, Makowski A, Misztal B. Using a high-flow respiratory system (Vapotherm®) within a high dependency setting. Nurs Crit Care. 2008 Oct 19; 13(6): 298-304. (Clinical Trial, Observational, Not Randomized, Single Site, n=72)

Rojas J, Miller T. The use of single prong nasal cannula to delivery high flow therapy on neonates.

Saslow J, Aghai Z, Nakhla T, Hart J, Lawrysh R, Stahl G, Pyon K. Work of breathing using high-flow nasal cannula in preterm infants. J Perinatology. 2006; 26: 476-80. (Mechanistic: Human, Prospective, Repeated Measures, Single Site, n=18)

Spivey S, Ashe T, Dennis R, Graham R, Melton B, Crot S, Ellis T, McCarl T, Miller J, Anderson S, Green T, Dunlap C, Kolnsberg M, Miller T. Assessment of high flow nasal cannula therapy use in the emergency department setting: observations of practice across four systems. Respiratory Therapy. 2015: 10(1); 30-4. (Non-Peer Reviewed, Prospective, Not Randomized, Multicenter, n=129)

Tero E, Cecich J, Sanabria O, et. al. Risks associated with conventional humidifiers adapted for high-flow nasal cannula therapy in human infants: results of a time and motion study. Int. J Clin Pediatr. 2014; 3(4): 99-104. (Clinical Trial, Observational, Not Randomized, Multicenter, n=109)

Waugh J, Granger W. An evaluation of 2 new devices for nasal high-flow gas therapy. Respiratory Care. 2004 Aug; 49(8): 902-906. (Bench)