Clinical Research

Research in high flow therapy: Mechanisms of action

Topic: Mechanisms Of Action Overview

Author: Dysart
Journal: Respiratory Medicine
Year: 2009

Impact of heated humidified high flow air via nasal cannula on respiratory effort in patients with chronic obstructive pulmonary disease.

Topic: Flush

Author: Atwood
Journal:
Chronic Obstructive Pulmonary Diseases
Year:
2017

High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model.

Topic: Flush

Author: Frizzola
Journal:
Epub
Year:
2010

Computational fluid dynamics modeling of extrathoracic airway flush: evaluation of high flow nasal cannula design elements.

Topic: Flush

Author: Miller
Journal:
Journal of Pulmonary Medicine & Respiratory Research
Year:
2016

What is optimum humidity?

Topic: Humidification

Author: Rankin
Journal: Respiratory Care Clinics of North America
Year: 1998

An Evaluation of 2 New Devices for Nasal High-Flow Gas Therapy.

Topic: Humidification

Author: Waugh
Journal:
Respiratory Care
Year:
2004

Work of breathing using high-flow nasal cannula in preterm infants.

Topic: Pressure – Neonatal

Author: Saslow
Journal:
Journal of Perinatol
Year:
2006

High flow through a nasal cannula and CPAP effect in a simulated infant model.

Topic: Pressure – Neonatal

Author: Volsko
Journal:
Respiratory Care
Year:
2011

High-Flow Oxygen Therapy: Pressure Analysis in a Pediatric Airway Model.

Topic: Pressure – Pediatrics

Author: Urbano
Journal: Respiratory Care
Year: 2012

Children with respiratory distress treated with high-flow nasal cannula.

Topic: Pressure – Pediatrics

Author: Spentzas
Journal:
Journal of Intensive Care Medicine
Year:
2009

Randomised control trial of oxygen assist module* in preterm infants on high-flow nasal cannula support

Topic: Automated Oxygen Control

Author: Nair 
Journal: Archives of Disease in Childhood – Fetal and Neonatal Edition
Year: 2023

*The oxygen assist module is not currently available for sale in the U.S. 

Nasal high-flow therapy as primary respiratory support for preterm infants without the need for rescue with nasal continuous positive airway pressure, Neonatology.

Topic: Primary Support – NICU

Author: Zivanovic
Journal: Neonatology
Year: 2019

Heated, Humidified High-Flow Nasal Cannula vs Nasal Continuous Positive Airway Pressure for Respiratory Distress Syndrome of Prematurity: A Randomized Clinical Noninferiority Trial

Topic: Primary Support – NICU

Author: Lavizzari
Journal: JAMA Pediatrics
Year: 2016

A randomized pilot study comparing heated humidified high-flow nasal cannulae with NIPPV for RDS

Topic: Primary Support – NICU

Author: Kugelman
Journal:
Pediatric Pulmonology
Year:
2015

Stabilisation of premature infants in the delivery room with nasal high flow.

Topic: Primary Support – Delivery Room

Author: Reynolds
Journal:
Epub
Year:
2016

Stabilisation of the preterm infant in the delivery room using nasal high flow: A 5—year retrospective analysis.

Topic: Primary Support – Delivery Room

Author: Siva
Journal:
Acta Paediatrica
Year: 2021

A randomized controlled trial to compare heated humidified high-flow nasal cannulae with nasal continuous positive airway pressure postextubation in premature infants.

Topic: De-escalation Support

Author: Collins
Journal:
The Journal of Pediatrics
Year:
2013

Nasal High-Flow Therapy during Neonatal Endotracheal Intubation.

Topic: Intubation

Author: Hodgson
Journal:
The New England Journal of Medicine
Year:
2022

Randomised cross-over study of automated oxygen control for preterm infants receiving nasal high flow.

Topic: Automated Oxygen Control

Author: Reynolds
Journal:
Archives of Disease in Childhood – Fetal and Neonatal Edition
Year:
2019

Safety and long term outcomes with high flow nasal cannula therapy in neonatology: a large retrospective cohort study.

Topic: Long-term Pulmonary Outcomes

Author: McQueen
Journal:  
Journal of Respiratory and Pulmonary Medicine
Year:
2014

Economic impact of changes in neonatal intensive care unit ventilation strategies with the advent of new noninvasive ventilation techniques: a review and proposed assessment framework for high flow therapy as a routine respiratory support paradigm.

Topic: Economics

Author: Pietzsch
Journal:
Journal of Health Economics and Outcomes Research
Year:
2015

Risks associated with conventional humidifiers adapted for high-flow nasal cannula therapy in human infants: Results of a time and motion study. 

Topic: Economics

Author: Tero
Journal:
International Journal of Clinical Pediatrics
Year:
2014

Consensus approach to nasal high-flow therapy in neonates.

Topic: Guidelines

Author: Yoder
Journal:
Journal of Perinatology
Year:
2017

High-flow nasal cannula versus continuous positive airway pressure in critical bronchiolitis: a randomized controlled pilot.

Topic: Primary Support

Author: Cesar
Journal: Journal of Pediatric Intensive Care
Year: 2020

The Relationship between high flow nasal cannula flow rate and effort of breathing in children.

Topic: Flow Rates

Author: Weiler
Journal:  
The Journal of Pediatrics 
Year:
2017

High-Velocity Nasal Insufflation VS Noninvasive Positive Pressure Ventilation for COPD Exacerbation

NEW STUDY!
Topic: Primary Support

Author: Yamane
Journal: Critical Care Medicine
Year: 2024

High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure

Topic: Primary Support

Author: Frat
Journal: The New England Journal of Medicine
Year: 2015

High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non inferiority randomized trial

Topic: Primary Support

Author: Cortegiani
Journal: Critical Care
Year: 2020

Recent advances in the use of high flow nasal oxygen therapies

Topic: Mechanisms Of Action Overview

Author: Wyatt
Journal: Frontiers in Medicine
Year: 2022

High-velocity nasal insufflation in the treatment of respiratory failure: a randomized clinical trial.

Topic: Primary Support

Author: Doshi
Journal:
Annals of Emergency Medicine
Year: 2018

The ventilatory effect of high velocity nasal insufflation compared to non-invasive positive-pressure ventilation in the treatment of hypercapneic respiratory failure: a subgroup analysis.

Topic: Primary Support

Author: Doshi
Journal:
Heart Lung
Year:
2020

High-flow oxygen therapy application in chronic obstructive pulmonary disease patients with acute hypercapnic respiratory failure: a multicenter study.

Topic: Primary Support

Author: Plotnikow
Journal:
Critical Care Explorations
Year:
2021

HVNI vs NIPPV in the treatment of acute decompensated heart failure: Subgroup analysis of a multi-center trial in the ED.

Topic: Primary Support

Author: Haywood
Journal:
American Journal of Emergency Medicine
Year:
2019

Back to basics with newer technology: should we focus on reducing work of breathing earlier?

Topic: Work of Breathing

Author: Sciarretta
Journal:
Frontiers in Medicine
Year:
2022

The effects of high-flow vs low-flow oxygen on exercise in advanced obstructive airways disease.

Topic: Work of Breathing

Author: Chatila
Journal: CHEST
Year: 2004

Respiratory support for adult patients with COVID-19

Topic: Primary Support

Author: Whittle
Journal:
Journal of the American College of Emergency Physicians Open
Year:
2020

Preliminary Findings on Control of Dispersion of Aerosols and Droplets During High-Velocity Nasal Insufflation Therapy Using a Simple Surgical Mask: Implications for the High-Flow Nasal Cannula.

Topic: Aerosol Dispersion

Author: Leonard
Journal:
CHEST
Year:
2020