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Your one stop shop for everything you need to know about Mask-Free NIV.

Clinical Research

Learn more about applications of Vapotherm technology through clinical studies and research.

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A masked male clinician in scrubs and gloves holding a neonate

SHINE Trial Shows that Vapotherm® Improved Chances for Successful Intubation in Preterm Babies

The study, also known as the SHINE trial, followed a previously published protocol2 and examined whether use of high flow nasal cannula would improve the likelihood of first-time success of intubations in neonates. The authors concluded that this intervention does improve success by comparison to treatment as usual (TAU), which does not include supplemental oxygen. It’s worth noting that though the authors refer to the therapy as “nasal high-flow,” the trial was conducted using exclusively Vapotherm high velocity therapy, which is an advanced form of high flow.

How does Vapotherm High Velocity Therapy Compare to Noninvasive Positive Pressure Ventilation (NiPPV)?

Dr. Doshi High Velocity Nasal Insufflation in the Treatment of Respiratory Failure

Hospital Case Studies

Norman Regional Health System

Norman Regional Health System streamlines clinician workflow with Vapotherm® Units

Putnam County Hospital Logo

Putnam County Hospital saves money and improves patient experience with Vapotherm

Florida Hospital at Connerton Logo

Florida Hospital at Connerton provides greater opportunities for patients and fewer invasive procedures with Vapotherm

Gaylord Hospital Logo

Gaylord Hospital returns patients to the highest level of function with early mobilization using Vapotherm


A community hospital level II nursery reduces transports by over 80%

Madonna Rehabilitation Hospitals logo

Madonna Rehabilitation Hospitals improve patient outcomes with Vapotherm

Patient Case Studies

Use of High Velocity Therapy with Inline Nebulization in Avoiding Intubation and PICU admission in Status Asthmaticus complicated by a COVID-19 Infection

Asthma is the most common chronic disease in childhood. Acute asthma exacerbations are one of the most common reasons for presentation to the Emergency Department (ED) and for hospitalization in the pediatric age.

Use of High Velocity Nasal Insufflation in combination with servo controlled delivery

Ambulation, mobilization and training area crucial part within the management of severely dyspneic patients awaiting lung transplant.

Use of High Velocity Therapy for Reversing Pneumothorax

Pneumothorax, or the presence of air in the pleural cavity, is a frequent condition in clinical practice. The standards of conduct for the pneumothorax approach depends on the patient’s clinical conditions and the magnitude of pneumothorax.

Helping Avoid Intubation in Complex COVID-19

Vapotherm’s high velocity therapy is a tool for treating respiratory distress. Although individual results may vary, Vapotherm believes this case study is an example of the clinical benefit Vapotherm’s high velocity therapy can have on patient ambulation.

COPD Exacerbation

Vapotherm resulted in rapid improvement that is believed to have averted the use of mechanical ventilation and ICU admission.

COPD Exacerbation (CAH)

Hi-VNI Technology helped provide adequate ventilatory support for an AECOPD patient.

CHF Crisis

Vapotherm provided a decrease in work of breathing over conventional oxygen therapy.

NiPPV Intolerance

A patient who demonstrated increased anxiety with NIPPV finds success with Vapotherm.

Rescue from NiPPV & HFNC Failure

HVNI rescued a patient in acute respiratory failure receiving HFNO therapy post-extubation.

Severe Bronchiolitis

HVNI used effectively in the management of severe bronchiolitis in a small child.